My Antidepressant Isn’t Working Anymore - What Can I Do?


Managing a chronic mental illness like depression is an ongoing process, requiring adjustments in your regimen from time to time. It is therefore not uncommon for your prescription antidepressant to lose efficacy after a while. Whether this is due to a change in your circumstances, your body’s own tolerance to the drug, or some other trigger, the important thing to remember is to not give up! There are things you can do to help restore your mental health and wellness without losing the progress you’ve made thus far. Let’s look at the options available to you should you find yourself in this situation.


First, you should take a good hard look at your daily schedule and routine over the past few weeks. Have you been physically active at least once each day? Are you socializing with friends and loved ones? Often our depression is a self-perpetuating illness, discouraging us from engaging in activities which promote positivity and mental health. It is easy to slip up and get into a pattern of isolation and lethargy, especially for those suffering from clinical depression. Be honest with yourself, and if your daily routine could use a boost of social and physical activity, commit to making this change and follow through! You will be surprised at what a difference a week’s worth of such activity can make for your mental health.


If your routine adjustments fail to provide the solution for you, you should bring the situation to your primary care provider for your mental illness and discuss with them a potential medication adjustment in order to get back on track. There are supplemental antidepressant medications today which, when added to your existing prescription regimen, can provide the boost you need to get over this rough patch in your mental health. This is preferable to a deviation from your existing medication regimen, as the titration periods for such drugs make switching from one to another a somewhat lengthy process whose results will not be known for several weeks. Have an open discussion with your doctor about what you are going through and work together to chart a course back to mental health and stability for yourself.


Clinical depression is one of the most common mental health diagnoses in the United States today. Like many chronic illnesses, managing the symptoms can be difficult at times, especially as your body adjusts to your medication regimen and causes it to lose efficacy. However, there are steps you can take to correct this problem, both independently and along with your prescribing physician. The most important thing is to never lose hope or give up on your mental health. It is well worth the effort for you to maintain a healthy state of mind, and with help mental and emotional wellness is within your grasp!


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